Türkçe Bilgi: Dirty drug

Medisinal kimyacıların veya farmakologların kullandığı bir terim olan dirty drug birden fazla moleküler hedefe ya da reseptör üzerine aynı anda, agonist ve/veya antagonist olarak etki edebilen moleküllerdir. Bu terimin Türkçe karşılığı genellikle çok hedefli ilaç ya da çok hedefli etken maddedir. http://en.wikipedia.org/wiki/Dirty_drug References ^ P. Popik, P. Skolnick (1998). Pharmacology of Ibogaine and Ibogaine-Related Alkaloids. The Alkaloids 52, Chapter 3, 197-231, Academic Press, Editor: G.A. Cordell ^ K.R. Alper (2001). Ibogaine: A Review. The Alkaloids 56, 1-38, Academic Press (pdf) ^ http://medical-dictionary.thefreedictionary.com/kanamycin ^ Musk, P (2004). "Magic shotgun methods for developing drugs for CNS disorders". Discovery medicine 4 (23): 299–302. PMID 20704963. edit ^ Roth, B.; Sheffler, D.; Kroeze, W. (2004). "Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia". Nature reviews. Drug discovery 3 (4): 353–359. doi:10.1038/nrd1346. PMID 15060530. edit ^ Buccafusco, J. (2009). "Multifunctional receptor-directed drugs for disorders of the central nervous system". Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 6 (1): 4–13. doi:10.1016/j.nurt.2008.10.031. PMID 19110195. edit ^ Enna, S. J.; Williams, M. (2009). "Challenges in the Search for Drugs to Treat Central Nervous System Disorders". Journal of Pharmacology and Experimental Therapeutics 329 (2): 404. doi:10.1124/jpet.108.143420. PMID 19182069. edit ^ Frantz, Simon (2005). "Drug discovery: Playing dirty". Nature 437 (7061): 942–943. Bibcode 2005Natur.437..942F. doi:10.1038/437942a. PMID 16222266. edit ^ Hopkins, Andrew L. (2009). "Drug discovery: Predicting promiscuity". Nature 462 (7270): 167–168. Bibcode 2009Natur.462..167H. doi:10.1038/462167a. PMID 19907483. edit ^ Hopkins, A; Mason, J; Overington, J (2006). "Can we rationally design promiscuous drugs?". Current Opinion in Structural Biology 16 (1): 127–136. doi:10.1016/j.sbi.2006.01.013. PMID 16442279. edit ^ Hopkins, Andrew L (2008). "Network pharmacology: the next paradigm in drug discovery". Nature Chemical Biology 4 (11): 682–690. doi:10.1038/nchembio.118. PMID 18936753. edit ^ Jain, R. (2004). "Single-action versus dual-action antidepressants". Primary care companion to the Journal of clinical psychiatry 6 (Suppl 1): 7–11. PMC 486947. PMID 16001091. edit

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